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Moreover, spermidine inhibits histone acetyltransferase p300 (EP300), a protein that suppresses autophagy, thereby enabling the activation of autophagy-related genes (Atg) (Reference Madeo, Carmona-Gutierrez and Kepp18)

The disulfide bonds in certain proteins are oxidized by ROS which can affect their activity, especially in the tyrosine phosphatases superfamily [25]

Alternatively, use made be made of the local lymph node assay, the results of which can be interpreted to yield an objective estimate of relative sensitizing potency (Kimber & Basketter, 1997)

In this study, participants either were given Module 1 or 2