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The diabetic history (year of diagnosis and treatment commencement) was also documented

Disassembly of the I-B/NF-B complex leads to inactivation of I-B via ubiquitination and subsequent rapid degradation by the 26S proteosome

Recent studies have demonstrated that optimizing trace mineral nutrition can improve the productive performance and physiological status of ducks, and the enhanced bioavailability of nano-trace minerals may further increase their biological efficiency 31

However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention