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The experimental section mentions the detailed procedure

Accutane is the brand name for isotretinoin , a powerful prescription medication primarily used to treat severe nodular or cystic acne that hasnt responded to other treatments like antibiotics or topical medications

10.1038/s41389-021-00349-4 159

(2023) Adhesive ergothioneine hyaluronate gel protects against radiation gastroenteritis by alleviating apoptosis, inflammation, and gut microbiota dysbiosis