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While fortified foods and dietary sources from animal foods help healthy people, injections ensure therapeutic levels for cobalamin deficiency and neurological symptoms

Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)

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Essendon was ruled ineligible to compete in the 2013 AFL finals series, and would be relegated to finish ninth