glutathione persister cells cancer

glutathione persister cells cancer Drug-tolerant are vulnerable to GPX4 inhibition Drug-induced tolerant persisters in tumor:

Name: glutathione persister cells cancer Drug-tolerant are vulnerable to GPX4 inhibition Drug-induced tolerant persisters in tumor:
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Drug induced tolerant persisters in tumor: mechanism, vulnerability and perspective implication for clinical treatment Molecular Cancer Springer Nature Link Glutathione peroxidase 4dependent glutathione highconsumption drives acquired platinum chemoresistance in lung cancerderived brain metastasis Liu 2021 Clinical and Translational Medicine Wiley Online Library Oncology Reports Fighting Drug Resistance through the Targeting of Drug Tolerant Persister Cells

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Inadequacies in antioxidant enzymes or their compromised metabolism will increase the concentration of reactive oxygen species (ROS) and, in essence, cause oxidative stress