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SKU: 88457222219
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Description

The analysis shows that primitive protozoan parasites completely lack the TS/glutathione pathway

10.3233/JPD-212976 128 TaylorC.CrosbyI.YipV.MaguireP.PirmohamedM.TurnerR

In a study by Moro et al (73) on patient-derived xenografts (PDXs), metformin (100 mg/kg/day) partially inhibited the tumor growth of PDXs with wild-type LKB1 (maximum inhibition rate, 50.514.8%), but had no significant inhibitory effect on LKB1-mutant PDXs, and with increasing doses of metformin, p-AMPK expression was increased and Ki67 expression was decreased, indicating that LKB1-deficient tumors have an impaired ability to adapt to metabolic stress induced by metformin treatment