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7E-I), definitive evidence requires ATX-knockout models

In several preclinical lung cancer mouse models, treatment of KRAS-mutant lung adenocarcinoma (LUAD) with HG106 (a potent System X c inhibitor), significantly inhibited tumor growth and prolonged survival (Hu et al., 2020)

Atherosclerosis, which is usually characterized by slow plaque formation inside the artery walls, can also progressively constrict the mesenteric arteries, ultimately leading to critical stenosis and reduced perfusion