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A distinction is made between two nocturnal blood pressure profiles: o reduced dipping, characterized by an average nocturnal BP reduction 18 points has been validated as indicative of a sleep disturbance and warranting an additional diagnostic work-up with vPSG [151]

In that case, a persistently high level can signal severe disease, including liver and kidney conditions and some types of tumors

This moderate pressor effect is likely due to its nitric oxide scavenging effects 2 and this drug is sometimes used as an offlabel treatment for vasoplegic syndrome 3

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