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Rosiglitazone improves insulin resistance but does not improve exercise capacity in individuals with impaired glucose tolerance: A randomized clinical study

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The promotion of antigen presentation involves GILZ facilitating the process by which antigen-presenting cells display antigens to T cells, thereby initiating an immune response (351, 352)

Moreover, increasing lactate levels during ischemia restored the M2-like polarization of macrophages in an MCT1-dependent manner, and an increase in VEGF production by polarized macrophages generated a positive feedback loop that further stimulated angiogenesis and ultimately facilitated postischemia revascularization and the regeneration of damaged muscle 132