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Mol Med Rep (2020) 21(5):21317

For instance, the FDA's approval of GLP-1 agonists for both type 2 diabetes and obesity has prompted professional organizations to update their clinical guidelines, outlining specific recommendations for their use in various patient populations

Edema (limited use due to weak diuretic effect) Side Effects: - Metabolic acidosis (due to bicarbonate loss) - Hypokalemia - Paresthesia (tingling) - Renal stones (alkaline urine increases stone risk) - Drowsiness, confusion - Sulfa allergy reactions (as CAIs are sulfonamide derivatives) Contraindications: - Severe hepatic or renal dysfunction - Addisons disease - Pre-existing electrolyte imbalance - Sulfonamide hypersensitivity Precautions: - Monitor serum electrolytes and acid-base balance - Use with caution in patients with pulmonary obstruction (CO retention risk) Pregnancy Category: Use with caution topical forms (e.g., dorzolamide) may be safer than systemic forms