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Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies

Avak vina vskumov v poslednch dvoch desaroiach dokzala, e plazmatick hladina redukovanho L-glutathionu, redukovanho glutathionu neme vykazova hladiny v inch tkanivch a redukovan L-glutathin, redukovan glutathin m perorlnu biologick dostupnos

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At endpoint A, when compared with the CTRL group, no changes were found in the percentage of methylation of any of the evaluated positions in the cultures of MOD patients, while SEV patients had an hypomethylated CpG at chr17: 36,090,102 ( Figure 4 )