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In most of our animal studies, we used a mixture of 2 molecules of GHK to 1 molecule of copper ion to avoid the possible oxidative actions of free copper ion

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Using this system, compound W478 was identified as a previously unobserved SHMT2 inhibitor, which is distinguished from previously reported inhibitors of SHMT2, such as antifolate analogues and pyrazolopyran derivatives, by virtue of its unique chemical structure

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