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PD is characterized by dopaminergic neuron loss and -synuclein aggregation, exacerbated by GSH depletion in the substantia nigra (74)

Furthermore, children with IGF-1 deficiency-primary GH insensitivity or children with Laron syndrome who were treated with biosynthetic IGF-1 (165) showed increases in their serum alkaline phosphatase and serum procollagen and IGF-binding protein-3 (IGFBP-3) (165167)

Disclosure of interest: Manabesh Nath: nothing to disclose

While the FDA stressed that a causal link has not been proven, the agency noted a growing body of studies showing a possible association between prenatal acetaminophen use and later diagnoses of autism or ADHD