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ATP levels in the hippocampus and prefrontal cortex of CUMS depression model mice were reduced, but injecting ATP into the lateral ventricle may significantly enhance their depressive behavior (Shen et al., 2020)

For example, the IKK overexpression could suppress the insulin pathway, and IKK genetic deletion alleviated the course of insulin resistance in the obese animal model, such as HFD-induced and Lep ob/ob obese mice [108]

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among patients with PD and poorer cognitive function, CSF iron levels are significantly elevated while transferrin levels are significantly reduced (82)