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The cellular localization of SdeA is not affected by self-ubiquitination or by SidJ Members of the SidE family undergo self-ubiquitination, the biological significance of which is unclear 20

The Wnt2/-catenin pathway, activated in many types of cancers and playing a significant role in its progression, is also inhibited in response to SAMe treatment in retinoblastoma showing tumor growth reduction in a xenograft animal model [263]