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Ansamycin derivatives such as 17-AAG (tanespimycin) and 17-DMAG (alvespimycin) reduce tau and -synuclein oligomerization in AD and PD models by promoting their degradation via the ubiquitinproteasome system

Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn

Further, anticonvulsive drugs (e.g., Phenytoin) or hyperosmotic (e.g., Dexamethasone) therapy may be added to CaNa 2 EDTA infusion if needed

Key scientific concepts Given its important role in cell metabolism, the ability to monitor and model the glutamine metabolic pathways are highlighted