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This is a formidable barrier to research exploring its systemic effects via oral delivery

10.1016/j.imbio.2021.152126 57 KimC

Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid -peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimers disease