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Gefitinib inhibited the downregulation of ER by EGFR and restored the sensitivity of cells to tamoxifen to a certain extent (Jeong et al., 2019)

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As shown in Figure 4C, isolated aorta from 4.2 / mice displayed upregulation of Vcam1, Icam1, and thromboxane synthase (Tbx) that are involved in vascular activation, cell adhesion, and platelet activation (43)