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Furthermore, cells in several types of cancers are characterized by significant enhancement of glutathione biosynthesis, and this metabolic vulnerability has been targeted to sensitize these cancer cells to ROS-induced drugs 63

The transcription of c-Fos , c-Jun , and Egr-1 in the mitogenic pathway was upregulated by 4.99, 7.05, and 3.70 folds, respectively

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Cuevasanta E., Reyes A.M., Zeida A., Mastrogiovanni M., De Armas M.I., Radi R., Alvarez B., Trujillo M