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The B group vitamins are closely concerned with carbohydrate/fat metabolism and protein synthesis (particularly haemopoiesis), indicating a large continuous requirement

doi: 10.3109/00365521.2015.1092576

Front Neuroendocrinol 73: Rissman RA, Lee KF, Vale W, Sawchenko PE (2007) Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation