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10.3390/genes13010131 78 LiznevaD.Gavrilova-JordanL.WalkerW.AzzizR

This dimer or tetramer enzyme, containing catalytic copper ions, relies on VIC to reduce Cu 2+ ions at the active site and activate oxygen, enabling dopamine hydroxylation to norepinephrine

Emerging evidence reported the role of glutamine mediating reductive carboxylation for lipid biosynthesis and also for redox homeostasis in cancer with dysfunctional mitochondria or under hypoxia [34,41-43]