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In a case report from Germany, the systemic administration of acetylsalicylic acid, diclofenac, ketotifen, ranitidine, tramadol, or tilidine combined with naloxone did not provide adequate pain relief

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This includes people who consume a diet high in processed foods, engage in excessive alcohol consumption, or are under chronic stress

In conclusion, though the drugs mentioned above showed good efficacy in preclinical or clinical trials, many tests and a long time would be required to apply to clinical treatment