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Ultimately, within the EGFR-mutated NSCLCs TME, significant Treg inroad exists in the setting of the non-inflammatory TME

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This review has highlighted the complexity and heterogeneity of NSCLC metabolism, revealing that tumors do not uniformly rely on a single metabolic pathway but rather exhibit plasticity, utilizing glycolysis, OXPHOS, glutaminolysis, fatty acid metabolism, and other pathways in context-dependent manners