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Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137

It is generally administered either into a muscle (intramuscularly) or a vein (intravenously)

Although joint disease typically follows the onset of skin psoriasis, in around 15% of cases it is the initial presentation, which can result in diagnostic delays