foxo4-dri peptide senolytic animal model 2023

foxo4-dri peptide senolytic animal model 2023 UK | Research The disordered p53 transactivation domain

Name: foxo4-dri peptide senolytic animal model 2023 UK | Research The disordered p53 transactivation domain
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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOXO4 DRI: Human Trial Status, Cancer Research & Senolytic Data The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv

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