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Consider a drug with a high extraction ratio of E = 0.9, resulting in an oral bioavailability of F = 10% (1 - 0.9)

Figure 1 D1-like DRs are coupled to the stimulatory G-subunit, Gs, whereas D2-like DRs, are coupled to the inhibitory G-subunit, Gi

While Dihexa itself is not yet approved for widespread medical treatments, it is accessible through research libraries and specialized peptide vendors

*Correspondence: Frederic Michon [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers