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made mesoporous silica NPs to resemble viral shapes and found that they could cross the BBB both in vivo and in vitro without any structural modifications to brain tissue[130]

C.FischbachK.PachecoG

The positron emission tomography (PET) was used to examine brain oxygen consumption and cerebral blood flow and revealed that patients with overt hepatic encephalopathy and those with liver cirrhosis without overt hepatic encephalopathy had a lower cerebral metabolic rate of oxygen and cerebral blood flow than healthy subjects 4