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Agarwal B, Swisher S, Ajani J, Kelly K, Fanning C, Komaki RR, Putnam JB, Abu-Hamda E, Molke KL, Walsh GL, Correa AM, Ho L, Liao Z, Lynch PM, Rice DC , Smythe WR, Stevens CW, Vaporciyan AA, Yao J, Roth JA

Pushpakumar et al., 2017)

Dose selection, absorption, titration and adherence matter more than the administration route, and treatment choice should be guided by patient preference, tolerability and real-life fit

Treatment of human dermal fibroblasts with acivicin, which inhibits -GT and restricts GSH import to mammalian cells 43 , as it does in worms, results in a substantial transcriptomic change (Supplementary Data 3)