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MSCs exert their therapeutic effects on PNI possibly through their dual functions, multipotent differentiation capacity into neural type of cells and their paracrine secretion of an array of bioactive factors with multiple trophic effects on both neural and nonneural cells [13], whereby the potent immunomodulatory effects of MSCs on immune cells, particularly macrophages, may constitute one of the major mechanisms by which MSCs exert their therapeutic effects on PNI [14]

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There have been no reports of cross sensitivity between lidocaine hydrochloride and procainamide or between lidocaine hydrochloride and quinidine

Based on the crucial role that ROS play in the pathology and pharmacological treatment of a wide range of diseases, therapeutic strategies targeting the regulation of ROS homeostasis hold significant clinical value for revealing the molecular mechanisms of diseases, promoting drug development, and advancing personalized treatment