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-secretase cleaves Notch to release the Notch intracellular domain (NICD), which translocates to the nucleus and binds RBPJ ( R ecombination Signal B inding P rotein For Immunoglobulin K appa J Region) to form a transcription factor that regulates expression of genes involved in proliferation, differentiation, and cell survival [30]

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The two components gp91 phox and p22 phox stabilise one another in a tightly associated heterodimer complex, referred to as flavocytochrome b 558 [17]

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