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Interestingly, we used a Tg(Xla.Tubb:bcl-2) transgenic line, in which zebrafish bcl-2 mRNA is overexpressed specifically in neurons under the control of a Xenopus neuron-specific -tubulin ( Xla.Tubb ) promoter, and Bcl-2 overexpression considerably reduced the number of apoptotic neuronal cells, which had been increased by sulindac (Fig

In the case of oculodermal melanosis or primary acquired melanosis, the risk of melanoma is much increased

High NRF2 expression stimulated GBM cell proliferation and facilitated the oncogenic transformation