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While increased surface area and dense ligand presentation can enhance local drug concentration and enable sustained, controlled release, these same features can intensify chemical interactions with host cells and increase toxicity [148]

NO disrupts this pathway by inhibiting HIF-1 accumulation, as shown by Graham et al

All of these health problems may lead to an infection, which could be life-threatening if left untreated

Current status and access Cibinetide has been granted US and EU Orphan Drug Designation for sarcoidosis treatment and received US Orphan Drug and Fast Track designations for neuropathic pain in sarcoidosis patients