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It is important to note that most in vitro data supporting the vulnerability of OPCs to ROS used normoxic conditions, potentially meaning altered levels of ROS compared to normal CNS homeostasis [170]

Genetic variations in genes coding for innate immune receptors including nucleotide-binding oligomerization domain (NOD)-2, mannan-binding lectin (MBL), and MBL-associated serine protease (MASP)-2 are associated with increased short-term mortality in ACLF and patients with acute decompensation (39)