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Consistency: Antioxidant levels build up over time

As the first line of immune defense in the CNS, microglia mediate neuroinflammatory responses by releasing pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor- (TNF-), and interleukin-6 (IL-6), disrupting neuronal homeostasis and accelerating the development of morphine tolerance ( Currently, no drugs have been approved for clinical use specifically to prevent or reverse morphine tolerance