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Furthermore, it has been described that ALA induces mitochondrial biogenesis by increasing the SIRT1 and PGC1 expression, which have neuroprotective properties, reducing oxidative stress, inflammation and preventing cell death [85, 86].The inhibition of PPAR using T0070907 [87, 88], avoided the beneficial effect of ALA, suggesting that PPAR activation is at least one of the key mechanisms through which ALA ameliorates the mutant phenotype of FRDA fibroblasts

Using rosemary, turmeric/curcumin, milk thistle, and Gingko bilioba may also positively impact glutathione status

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The added complexity of the cysteine targets that compose part of a Zn binding site found for Hsp33 and RsrA raises questions about the function of the zinc