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MTHFR mutations are commonly associated with high homocysteine levels 3 and low methionine production, which in turn may lead to the accumulation of S-adenosylhomocysteine (SAH) and low levels of SAMe

Statistical Analysis Univariate analyses were performed to compare fold changes, calculate the areas under the curve (AUC) and determine statistical significance

2.1.1.1 All- trans retinoic acid (ATRA) CD38 expression can be modulated both in vitro and in vivo through the nuclear retinoic acid receptor ( in vivo use, has proven effective in enhancing CD38 levels in several ex vivo myeloma cell preparations, leading to improved efficacy of therapeutic antibodies ( in vivo efficacy in combination with Daratumumab was called into question in a clinical trial involving relapsed/refractory (RR) MM patients

doi: 10.1007/s12035-016-0170-2 430 De BellisABellastellaGPerniceVCirilloPLongoMMaioAet al