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These stressors could be not getting sufficient sleep, smoking, food intolerances, diets high in sugars and processed foods, excess alcohol intake and hormone or immune imbalances

10.1124/pr.57.2.5 12 FuchsE

First, the current body of evidence lacks large-scale, long-term randomized controlled trials (RCTs) evaluating the sustained effects of specific diets and herbal supplements in diverse populations

In fact, circulating MOTS-c levels are shown to increase with exercise and, much like GHK-Cu and other endogenous peptides, natural levels of MOTS-c tend to decrease with age, and for this reason it has gained interest in the field of aging research