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Across multiple drug classes, common patterns emerge: Corticosteroids accelerate protein breakdown and deplete calcium, vitamin D, magnesium, zinc, and vitamin Cnutrients required for bone strength, collagen synthesis, and immune repair Acetaminophen consumes glutathione, increasing oxidative stress and impairing cellular recovery NSAIDs interfere with iron, folate, and vitamin C absorption while disrupting prostaglandin-driven tissue healing Opioids suppress endocrine and immune signaling necessary for regeneration Individually, these effects may appear modest

FalangaVIwamotoSChartierMYufitTButmarcJKouttabNet alAutologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds

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Injections offer rapid results but are expensive, can have side effects, and require frequent clinic visits