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Additionally, inhibition of CD38 in the AD mouse model restored NAD + levels, decreased mitochondrial ROS production and plaque depositions in the hippocampus and cortex, and improved cognitive abilities 158

Taub 2 , Ya-Yun Ren 3 , Elaine Lay Khim Chng 1 and Stephen A Harrison 4 , (1)Histoindex Pte Ltd, Singapore, (2)Madrigal Pharmaceuticals, (3)Histoindex Pte Ltd, (4)Pinnacle Clinical Research Center, San Antonio, TX Background: Resmetirom is an oral, liver-targeted thyroid hormone receptor- selective agonist that reduces biopsy component scores