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On the other hand, Dave and coworkers found a disruption of the Calu3 ALI monolayer infected with R001, N222.1, and N459.6 meningococcal strains, suggestive of a paracellular route of epithelial crossing (Dave et al., 2023)

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Moreover, the signs of ferroptosis in intestinal epithelial cells, including the upregulation of intracellular iron levels and lipid peroxidation, the increase in PTGS2 mRNA levels, the downregulation of GPX4 mRNA and GSH levels, and significant mitochondrial damage are significantly relieved by deferoxamine treatment (37)