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Traditional Chinese medicine compounds such as the Yangxinshi tablet (containing Astragalus membranaceus, Salvia miltiorrhiza, Codonopsis pilosula, etc.) have demonstrated the ability to modulate mitochondrial bioenergetics in preclinical models, although they have not yet entered formal clinical trials

Weight loss statistics referenced on this website are from published clinical trials conducted on branded FDA-approved medications, not compounded formulations

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However, l-dopa possesses many pharmacokinetic and pharmacodynamic drawbacks leading to pulsatility (short half-life), reduced availability (limited and variable reabsorption, and the requirement for declining aromatic l-amino acid decarboxylase), and off-target metabolism and sites (endothelium, glial cells, serotonin neurons and so on)