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105 HSF2 can regulate the mitochondrial phagocytosis of intestinal epithelial cells via the PARL/PINK1/Parkin pathway, removing damaged mitochondria, decreasing the levels of mtROS in cells, suppressing intestinal mucosal inflammation, and maintaining the intestinal environment balance in UC

The DAMP function of HSP70 is so well recognized that the so-called Heck indexthe ratio of extracellular to intracellular HSP70 levelshas been widely implemented as a marker of inflammatory status (Soldatov et al., 2024

4), 2SS1 and 3KGLwere retrieved from the Protein Data Bank (PDB) for structural analysis

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