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Age influences microglial activation after cuprizone-induced demyelination

Thats why awareness and understanding are key

In contrast, in IFN-R / mice cuprizone-induced microglia accumulation was initially diminished or simply delayed (Mana et al., 2006) that was reflected at week 3 of cuprizone diet by a reduced expression of microglia-associated molecules such as IGF-1 and TNF- that have been proposed to promote proliferation of OPC