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Furthermore, patient information and sample handling procedures should be as detailed as possible as concomitant disease, systemic inflammation, infections and medication intake as well as post-mortem tissue preparation/fixation and storage protocols could affect results and subsequent interpretation of findings (Gomez-Nicola and Boche, 2015)

Pegvisomant increases the metabolic rate of food-deprived mice To assess whether the energy-conserving effects of GH can be pharmacologically manipulated, we tested in mice the effects of a clinically available GHR antagonist (pegvisomant)

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