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The analgesic effect of BTX-A has been investigated through a series of open-labeled studies as well as a few randomized controlled trials (RCTs), with an increasingly strong evidence that botulinum toxin injections are efficacious, thus placing it as a treatment option either before surgery or for those with intractable trigeminal neuralgia and unwilling to undergo surgery, however, a more placebo-controlled clinical trials are still needed to confirm these findings

de Oliveira MR, Peres A, Gama CS, Bosco SMD (2017) Pinocembrin provides mitochondrial protection by the activation of the Erk1/2-Nrf2 signaling pathway in SH-SY5Y neuroblastoma cells exposed to paraquat

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