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TNF- is additionally associated with recurrent oral ulcers, and administering TNF- inhibitors to oral ulcers resulted in reduced neutrophil recruitment and reduced inflammation, but also reduced fibroblast migration, maturation, and angiogenesis due to the lack of neutrophilic chemokines and growth factor release [66]

The relationship between B12 and mental health is well established in medical literature, though it is primarily characterised by the psychiatric consequences of deficiency rather than excess

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However, the overproduction or dysregulation of these cytokines induced by pyocyanin can lead to persistent inflammation, contributing to chronic inflammatory diseases such as CF and advanced stages of COPD