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In the pancreatic cancer cells tested, delivery of supraphysiologic levels of ubidecarenone specifically affected succinate (Complex II) and glycerol-3-phosphate (GPDH)-fuelled respiration, with non-inhibitory effects on pyruvate (Complex I)-fuelled respiration

This state is unsustainable and places a significant metabolic burden on the body, setting the stage for the next phase of dysregulation

In rodent models of cardiovascular injury, metabolic syndrome, and oxidative stress, EGT supplementation has been associated with reductions in lipid peroxidation markers, improved antioxidant enzyme activity, and preservation of mitochondrial ultrastructure

doi:10.1016/j.phymed.2022.153928 36