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Upregulation of TLR4 was observed in the renal tubules of DKD biopsies and positively correlated with interstitial macrophage infiltration

The increase in activity of AST and ALP in glucose fed-worms could be interpreted as a sign of aging, as a similar increase is observed in aged worms [38, 39], and could indicate that glucose exposure is accelerating aging in worms, as has been hypothesized previously [11, 49]

Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma