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They further refined the in vivo and in vitro experiments and found that andrographolide enhanced nuclear translocation of Nrf2 and increased the expression of antioxidant genes, alleviating APAP-induced liver oxidative stress damage in mice and reducing HSC activation (Yan et al., 2018b)

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thus amplifying the response

Another study showed that daily consumption of silymarin can lower HbA1c levels (a laboratory value reflecting 3-month average blood sugar levels)