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There is significant evidence to suggest a role of microglia in promoting neurogenesis by phagocytosing apoptotic neural progenitor cells, facilitating the migration and differentiation of neural progenitor cells and secreting soluble factors which promote neurogenesis (Lira-Diaz and Gonzalez-Perez, 2016)

However, they can be great to have on hand when needed, and it may be worth experimenting with taking DAO for a week or so to see if it helps your sleep

Annu Rev Plant Biol 49:427451

Notably, Smad3 , which acts primarily downstream of the TGF-activin pathway and is predicted to drive early gene expression changes in HD 23 , was significantly upregulated in the iSPN + mut subpopulation at 8 months (Extended Data Fig